Professor Schmid and Dr. Jiabei Yang recently had a paper published using N-of-1 trials investigating the effect of two diets for treating patients with inflammatory bowel disease. in collaboration with colleagues at the University of Cincinnati. The studies found that both diets worked for some, but not all patients.

The study used innovative Bayesian methods to estimate both individual and group treatment effects. The figure shows the posterior probabilities of benefit, harm or equivalence for each patient in the study grouped according to their study completion status.

The paper was published in the American Journal of Gastroenterology.

Kaplan, Heather C. MD, MSCE1,2,3,*; Opipari-Arrigan, Lisa PhD2,3,4,*; Yang, Jiabei MS5; Schmid, Christopher H. PhD5; Schuler, Christine L. MD MPH3,6; Saeed, Shehzad A. MD7; Braly, Kimberly L. RDN8; Chang, Fandi BA, BS5; Murphy, Lauren BA2; Dodds, Cassandra M. MA2; Nuding, Mason BS9; Liu, Hao BS10; Pilley, Sheri BA11,12; Stone, Julie11,13; Woodward, Gisele MSW11,14; Yokois, Nancy MD15; Goyal, Alka MD16,17; Lee, Dale MD, MSCE8; Yeh, Ann Ming MD17; Lee, Peter MD18; Gold, Benjamin D. MD14; Molle-Rios, Zarela MD19; Zwiener, R. Jeff MD20; Ali, Sabina MD21; Chavannes, Mallory MD, MHSc22,23; Linville, Tiffany MD24; Patel, Ashish MD25,26; Ayers, Travis MD27; Bassett, Mikelle MD28; Boyle, Brendan MD29; Palomo, Pablo MD30; Verstraete, Sofia MD, MAS31; Dorsey, Jill MD, MS32; Kaplan, Jess L. MD33; Steiner, Steven J. MD34; Nguyen, Kaylie MS, PNP35; Burgis, Jennifer MD31; Suskind, David L. MD8;  for the ImproveCareNow Pediatric IBD Learning Health System Personalized Research on Diet in Ulcerative Colitis and Crohn's Disease: A Series of N-of-1 Diet Trials, The American Journal of Gastroenterology: June 2022 - Volume 117 - Issue 6 - p 902-917

doi: 10.14309/ajg.0000000000001800